Latest scientific findings
A previous genome-wide linkage scan conducted in EGEA showed a strong evidence of linkage of the 1p31 region to the combined asthma plus rhinitis phenotype. MH Dizier et al. recently conducted a fine-scale mapping in this region and for the first time identified a genetic variant located nearby the NFAI gene, a strong candidate gene for asthma plus rhinitis. (Read more - Dizier MH, et al. The nuclear factor I_A (NFIA) gene is associated with the asthma plus rhinitis phenoype. J Allergy Clin Immunol. 2014 Feb 20)
The heterogeneity of asthma have poorly been considered in genetic studies, in particular in genome-wide association studies (GWAS). A GWAS has been conducted for 4 comprehensive asthma phenotypes identified by a clustering method in the EGEA ECRHS and SAPALDIA asthmatic population. Associations were abserved between some genetic variants and specific asthma phenotypes. (Read more - Siroux V, et al. Genome heterogeneity of comprehensive asthma phenotypes identified by a clustering approach. Eur Respir J. 2014 Feb)
A recent study by Dumas O et al strenghten the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in this association. (Read more - Dumas O, et al. Cleaning and asthma characteristics in women. Am J Ind Med. 2014 Mar)
The EGEA study tooks part to three large genetic studies on asthma or asthma-related phenotypes that suggested : 1) the protective role of a genetic variant (genomic inversion in the 16p11.2 region) against the joint occurrence of asthma and obesity (Gonzales et al. A common 16p11.2 inversion underlies the joint suscepptibility to asthma and obesity. Am J Hum Genet. 2014 Mar 6) and 2) the modifier effect of some genetic variants in the relation between tobacco smoke exposure (in utero or in childhood) in the developpment of asthma in childhood (Schotlens et al. Novel childhood asthma genes interact with in utero and early life tobacco smoke exposure. J Allergy Clin Immunol. 2013 Dec 5) and 3) the role of three genetic factors ( located in or nearby the LYR, NOS2 and GSDMB genes) in the FeNO values in children. (Van der Valk et al. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2013 Dec 5).