Latest scientific findings
- A review (in French) summarize the results of the phenotypic characterization and the investigation of environment and genetic factors of asthma and asthma-related phenotypes obtained since 2007 in the EGEA study (42 articles). (read more: Bouzigon et al. Facteurs génétiques et environnementaux de l’asthme et de l’allergie; Etude EGEA : Synthèse des résultats. Rev Mal Respir. 2015 Mar 17).
- The EGEA study took part to a European study aimed to assess the long terme effects of air pollution on human health (ESCAPE). Results suggests a role of chronic exposure to air pollutants on lung function level (read more: Adam et al. Long-term exposure to air pollution and lung function in adults: multicentre cohort study and meta-analysis, the ESCAPE project. Eur Respir J. 2015;45:38-50) and on adult-onset asthma (read more: Jacquemin et al. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environ Health Perspect. 2015 Feb 24. [Epub ahead of print])
- Bouzigon et al. identified a common variant located in RAB27A gene influencing FeNO levels specifically in adults, poviding new insight into the biological mechanisms underlying FeNO levels in adults (read more: Bouzigon et al. Common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults. Clin Exp Allergy. 2015 ;45:797-806)
- Sanchez et al. showed that a simple self-reported respiratory health transition question over 10 years allows predicting part of the long-term trajectory of asthma. (read more : Sanchez et al. Perceived long-term change in respiratory health: validity and predictive ability. Respir Med. 2015 ;109:188-99)