Some recent scientific results
- The role of modern lifestyle factors, including diet and obesity, has recently raised increasing interest in asthma. An analysis in the EGEA study, including nearly 1000 participants followed-up over seven years on average, suggested that high cured meat intake was associated with worsening asthma symptoms, and that this effect was partially mediated by obesity. (Read more: Li et al., Cured meat intake is associated with worsening asthma symptoms. Thorax 2016 Dec 20. [Epub ahead of print])
- Bleach is widely used for household cleaning. Although it is recognized that occupational use of bleach may have adverse respiratory health effects, it is unknown whether common domestic use of bleach may be a risk factor for asthma. We assessed whether the domestic use of bleach for home cleaning is associated with asthma and other respiratory outcomes. Frequent use of bleach for home-cleaning is associated with non-allergic adult-onset asthma, elevated neutrophil counts and lower-airway symptoms in women. (Read more: Matulonga et al. Domestic use of bleach for cleaning and non-atopic asthma in women. Respir Med. 2016;117: 264-71.)
- Differential exposure to air pollution could contribute to produce social inequalities in asthma. A recent study assessed and compared, in 16 European cities, the association between indicators of socioeconomic position at individual-level (educational level and social class) and area-level (neighborhood unemployment rate) and NO2 exposure, a marker of road traffic. For most cities, individual SEP was not associated to NO2 exposure. Participants living in neighborhood with higher unemployment rate were more exposed to NO2. The important heterogeneity of the associations suggested that differential exposure to air pollution is a complex phenomenon in Western Europe. This study stressed the importance of considering both individual- and neighborhood- indicators of socioeconomic position in air pollution health effects studies. (Read more: Temam et al., Socioeconomic position and air pollution exposure in Western Europe: a multi-city analysis. Environmental International 2016 (in press)).
- The biological mechanisms by which occupational exposures to low molecular weight (LMW) agents or irritants (from cleaning products and disinfectants) affect respiratory health remain incompletely evaluated. A collaborative study was initiated to identify genes involved in the response to oxydative stress, that play a role in the development of asthma when associated with these occupational exposures. We identified novel genes (PLA2G4A, PLA2R1, RELA, PRKD1 et PRKCA which play a role in the NF-kB pathway involved in inflammation) potentially involved in adult asthma in relation with these occupational exposures. (Reand more: Rava et al. Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies. Environ Health Perspect. 2016 Aug 9. [Epub ahead of print]).
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