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Some recent scientific results

  • The mechanisms by which obesity affects respiratory health, and in particular the activity of asthma, are poorly understood. A recent study shows that the association between obesity and the persistence of asthma over time is partly mediated by leptin (a pro-inflammatory protein secreted by adipose tissue). (Read more: Li et al. Role of leptin in the association between body adipodity and persistent asthma : a longitudinal study, Obesity 2019, in press)

  • Following a study that suggested that asthma and rhintis multi-morbidity is associated with allergic poly-sensitization (Siroux et al. Allergy 2018 Jul;73(7):1447-1458. doi: 10.1111/all.13410. Epub 2018 Feb 6), we have shown in a recent article that conjunctivitis is also involved in allergic poly-sensitization and brings additional information to asthma and rhinitis in allergic multimorbidity. These new observations suggest that the study of allergic multimorbidities should consider the three target organs, the nose, the eyes and the lower respiratory tract. (Rea more: Siroux V et al. Association between asthma, rhinitis, and conjunctivitis multimorbidities with molecular IgE sensitization in adults, Allergy 2019 Apr;74(4):824-827. doi: 10.1111/all.13676. Epub 2019 Jan 8.)

  • Clustering statistical methods led to the identification of specific asthma phenotypes, confirming the phenotypic heterogeneity of asthma, but the predictive ability of these phenotypes remained poorly studied. Thanks to the 20-year follow-up of the EGEA and ECRHS cohorts, we studied the long-term clinical course of seven asthma phenotypes defined by a statistical classification method. The characteristics of asthma (current asthma, exacerbations, asthma control, quality of life and FEV1) differed significantly between the seven asthma phenotypes identified 20 years earlier. These results indicate a high stability of the disease activity in the long term (read more: Boudier et al. Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later. Allergy 2018 Dec 13. doi: 10.1111/all.13697. [Epub ahead of print])

  • Following our study on the interactive effect in HRB of early-life environmental tobacco smoke (ETS) exposure with the DNAH9 gene (Dizier et al, ERJ, 2016) we performed a search for other genes interacting with the ETS for BHR by studying those involved in the ATPase binding and ATPase activity metabolic pathways. The two pathways were selected because 1 / they both include the DNAH9 gene, 2 / they are the target of cigarette smoke and 3 / they play a crucial role in the inflammation of the airways. This study identified two new genes involved in BHR and interacting with ETS, the ATP8A1 and ABCA1 genes that play a role in maintaining the asymmetry and homeostasis of pulmonary membrane lipids. (Read more: Diziez MH et al. Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families. Thorax 2018 Oct 3. pii: thoraxjnl-2018-211797. doi: 10.1136/thoraxjnl-2018-211797.)


 Complete list of references

 

Tutorials for the site EGEAnet

 Presentation of the EGEA study

 

Help to find various documents on the site of EGEAnet :

- Welcome on EGEAnet, the web site of the EGEA study

- Where can I find the "charte de confidentialité" ?

- Where can I find the composition of cooperative group EGEA ?

- Where can I find the form of access to the data ?

- Where can I find documents regarding regulatory aspects ?

- Where can I find EGEA questionnaires in public space ?